February 17th is GVHD Day
Graft-versus-host disease (GVHD)
A potentially serious complication of both allogeneic and reduced-intensity allogeneic stem cell transplantation arises from the process in which a patient’s own damaged or diseased blood-forming stem cells are destroyed and replaced with healthy donor stem cells.
What is GVHD?
GVHD develops when the donated stem cells (“the graft”) recognize the patient’s healthy cells (“the host”) as foreign and begin to attack them, leading to a condition known as graft-versus-host disease.
Types
These types differ in the organs and tissues they affect as well as in their symptoms. A patient may experience only one type, both types, or in some cases, may not develop GVHD at all.
Comparison Between Types of GVHD
| Acute GVHD | Features | Chronic GVHD |
|---|---|---|
| Inflammatory reaction post-transplant; mainly T-cell mediated |
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Autoimmune-like condition involving T cells, B cells, and fibrosis |
| Usually within first 100 days post-transplant (but can be later) |
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Usually after 100 days, but time-based classification is evolving |
| Red rash (maculopapular), starting on palms/soles and spreading |
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Lichen planus-like rash, skin thickening, pigmentation changes, sclerosis |
| Elevated bilirubin and liver enzymes |
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Cholestatic liver dysfunction, bile duct damage, fibrosis |
| Nausea, vomiting, watery diarrhea, abdominal pain |
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Dry mouth, esophageal strictures, weight loss |
| Rarely involved |
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Can affect lungs, eyes, joints, genitals, mouth |
| Clinical signs + biopsy showing epithelial apoptosis |
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Biopsy shows fibrosis, chronic inflammation, and immune dysregulation |
| High-dose corticosteroids; immunosuppressants |
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Corticosteroids + additional immunosuppressants (e.g., calcineurin inhibitors) |
| May be life-threatening in severe cases |
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Chronic, relapsing course with long-term morbidity |
| Mostly affects early post-transplant recovery |
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Major long-term impact on quality of life |
What WE OFFER
Reliable Information
Accessible resources to understand and manage GVHD.
Raising awareness
Organize and host educational meetings and webinars to provide valuable information and support.
Community Connection
Establish an NF community, providing support and resources to its members and families.
Heros with GVHD
Learn how to effectively support and empower individuals living with GVHD.
Know MoreGet Involved
We are building a strong and compassionate patient support group for those affected by Graft–versus–Host Disease (GVHD). Our goal is to unite patients, caregivers, and advocates to share their stories, learn from one another, and spread awareness. By joining our community, members not only find strength and support — but also empower others by raising awareness and driving meaningful change.
BE A PART
By becoming a part of our community, you contribute to a network of understanding, compassion, and shared experiences.
Be a MemberSHARE YOUR STORY
Your story can inspire hope, raise awareness, and help others feel they're not alone in their GVHD journey.
Know MoreFAQ
Doctors usually prescribe immunosuppressive medications to reduce the risk. Matching donor-recipient tissue types (HLA matching) also helps lower the chances of GVHD.
Treatment includes corticosteroids, immunosuppressive agents, and supportive care like skincare, nutrition, and infection prevention.
Yes, especially if it affects multiple organs or is not controlled. Early diagnosis is crucial.
GVHD can often be managed, and in some cases, it resolves. Chronic GVHD may persist and need long-term care.
This effect occurs when donor immune cells attack remaining cancer cells. Mild GVHD may indicate a strong GVT response.
Stick to meds, monitor infections, eat a balanced diet, and stay in touch with healthcare providers.
Yes, support groups and hospital services provide guidance and emotional support.
No. GVHD is a complication, but it doesn’t stop transplanted stem cells from working.
